Hodgkin disease results in enlargement of the lymph nodes and spleen. Whereas Hodgkin disease generally has a high cure rate, non-Hodgkin lymphomas are often more difficult to treat. Burkitt lymphoma is a non-Hodgkin type.
It is known that CD3 and CD20 are homogenously expressed in T lineage and B lineage lymphoma, respectively. CD20 and CD3 are commonly used as specific markers of B and T lineage lymphomas, respectively.
Pathological examination is the main means of diagnosis of lymphoma. The pathological diagnosis of lymphoma requires comprehensive application of morphology, immunohistochemistry, genetics and molecular biology techniques, and flow cytometry, etc.
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