INNOVATION FOR PATHOLOGY DIAGNOSIS
+86-37156596939
[email protected]
HOME
PRODUCT
SOLUTION
SERVICE & SUPPORT
ABOUT US
CONTACT US
P16/Ki-67 dual staining detection reagent kit (immunocytochemistry) is an detection reagent for cervical cell screening shunt and diagnosis of cervical tissue samples. It adopts immunohistochemical double-staining detection and multi-antibody combination technology. Two antigen targets, p16 and Ki-97, can be detected simultaneously on the same sample tissue section by one staining process. The p16 gene has the function of inhibiting cell proliferation during the cell cycle arrest period and is strongly expressed in cervical intraepithelial neoplasia and cervical cancer, which is an objective biomarker for cervical lesions. Ki-67 is a biomarker of cell proliferation, and its overexpression indicates that the cell is in the proliferation phase. Normally, the expressions of p16 and Ki-67 are mutually exclusive. The co-expression of p16 and Ki-67 indicates that the cell cycle is disordered and the cells continue to proliferate. p16 alone as the identification standard is required combining morphology and detected simultaneously with Ki67. The results are more reliable.
κ and λ are two types of light chains on immunoglobulins. The number of B cells expressing different light chains in normal lymph nodes κ:λ is about 2:1. The restricted expression of kappa or lambda shows monoclonal hyperplasia and tumor formation.
Masson trichrome method is one of the main methods of collagen fiber and myofibril staining, which has an important application in pathological examination.It is mainly utilized to distinguish collagen fiber and myofibrils, and can also be utilized for renopuncture. Addtionally, collagen fiber presents green or blue , but Myofibrils presents red. Thus,masson trichrome stain is also important for judging the precipitation of immune complexes.
The protein encoded by c-erbb-2 gene is a membrane-piercing protein with a molecular weight of 185kDa, which is a member of the large family of cell surface growth factor receptors and can inhibit tyrosine kinase activity. The over-expression of this gene is closely related to the judgment of breast cancer and the differentiation and classification of tumor.This antibody is mainly used as a reference index to judge the prognosis of breast cancer, ovarian cancer, endometrial cancer and gastrointestinal cancer.
Ki67 is a cell proliferation marker that is closely related to the cell cycle. There is expression in G1, S, G2, M period,there is no expression in G0 period. Its proliferation index is closely related to the degree of separation, leaching metastasis and prognosis of many tumors.
The MicroStacker™ technology allows well-controlled layered stacking of F(ab’) fragments of IgG secondary antibody and peroxidase enzymes on a micro-polymer scaffold, which results in a compact polymeric structure with superior sensitivity compared to other conventional HRP polymers with bulky dextran backbones. This system avoids the use of streptavidin and biotin, and therefore eliminates non-specific staining as a result of endogenous biotin. Herein, the Mouse-on-Mouse Polymer comprises of specially engineered anti-Mouse secondary antibody to eliminate the high backgrounds caused by endogenous mouse antibodies in mouse tissues.
MicroStacker™ Polymer Detection System is a biotin-free, polymeric horseradish peroxidase (HRP)- secondary antibody conjugate system for the detection of mouse and rabbit primary antibody on formalin-fixed, paraffin-embedded (FFPE) tissues in an immunohistochemistry (IHC) procedure. The innovative MicroStacker™ technology allows well-controlled layered stacking of antibodies and peroxidase enzymes on a micro-polymer scaffold. This technique results in a compact polymeric structure that easily penetrates to all cellular compartments. Plus, the system utilizes F(ab’) fragments of IgG secondary antibody instead of the whole IgG, which avoids the background caused by non-specific binding of whole IgG to endogenous Fc receptors. Compared to the MicroStacker™ Polymer Detection System, Universal, the Enhanced kit comes with the HRP polymer at a higher degree of polymerization, thus higher sensitivity.
MicroStacker™ Polymer Detection System Universal is a biotin-free, polymeric horseradish peroxidase (HRP)- secondary antibody conjugate system for the detection of mouse and rabbit primary antibody on formalin-fixed, paraffin-embedded (FFPE) tissues in an immunohistochemistry (IHC) procedure. The innovative MicroStacker™ technology allows well-controlled layered stacking of antibodies and peroxidase enzymes on a micro-polymer scaffold. This technique results in a compact polymeric structure that easily penetrates to all cellular compartments, which provides superior sensitivity compared to other conventional HRP polymers with bulky dextran backbones. Plus, the system utilizes F(ab’) fragments of IgG secondary antibody instead of the whole IgG, which avoids the background caused by non-specific binding of whole IgG to endogenous Fc receptors.
MicroStacker™ Polymer Detection System is a biotin-free, polymeric horseradish peroxidase (HRP)- secondary antibody conjugate system for the detection of mouse and rabbit primary antibody on formalin-fixed, paraffin-embedded (FFPE) tissues in an immunohistochemistry (IHC) procedure. The innovative MicroStacker™ technology allows well-controlled layered stacking of antibodies and peroxidase enzymes on a micro-polymer scaffold. This technique results in a compact polymeric structure that easily penetrates to all cellular compartments. Plus, the system utilizes F(ab’) fragments of IgG secondary antibody instead of the whole IgG, which avoids the background caused by non-specific binding of whole IgG to endogenous Fc receptors. The degree of polymerization of enzymes and antibodies is upgraded with higher sensitivity. The optimal effect can be achieved simultaneously in the mouse/rabbit primary antibody. MicroStacker™ Plus HRP-polymer detection kit is suitable for various types of automatic immunohistochemistry stainer.
MicroStacker™ Polymer Detection System is a biotin-free, polymeric horseradish peroxidase (HRP)- secondary antibody conjugate system for the detection of mouse and rabbit primary antibody on formalin-fixed, paraffin-embedded (FFPE) tissues in an immunohistochemistry (IHC) procedure. The innovative MicroStacker™ technology allows well-controlled layered stacking of antibodies and peroxidase enzymes on a micro-polymer scaffold. This technique results in a compact polymeric structure that easily penetrates to all cellular compartments. Plus, the system utilizes F(ab’) fragments of IgG secondary antibody instead of the whole IgG, which avoids the background caused by non-specific binding of whole IgG to endogenous Fc receptors. According to your needs, the linker (mouse/rabbit) can be flexibly selected to further improve the staining effect. MicroStacker™ Flex HRP-polymer detection kit (mouse/rabbit linker) can be commonly used for detection of murine and rabbit antibodies. The Flex kit is suitable for various types of automatic immunohistochemistry stainer.
MicroStacker™ Polymer Detection System Universal is a biotin-free, polymeric horseradish peroxidase (HRP)- secondary antibody conjugate system for the detection of mouse and rabbit primary antibody on formalin-fixed, paraffin-embedded (FFPE) tissues in an immunohistochemistry (IHC) procedure. The innovative MicroStacker™ technology allows well-controlled layered stacking of antibodies and peroxidase enzymes on a micro-polymer scaffold. This technique results in a compact polymeric structure that easily penetrates to all cellular compartments, which provides superior sensitivity compared to other conventional HRP polymers with bulky dextran backbones. Plus, the system utilizes F(ab’) fragments of IgG secondary antibody instead of the whole IgG, which avoids the background caused by non-specific binding of whole IgG to endogenous Fc receptors. After mouse/rat serum cross-adsorption, MicroStacker™ Rabbit-on-Rodent HRP-polymer detection kit can significantly reduce non-specific staining caused by endogenous immunoglobulin. The kit is mainly used for rabbit monoclonal antibody/rabbit polyclonal antibody on mouse/rat tissues staining.
2022.03
CELNOVTE BIO-TECH Booth#1001. USCAP 2022 Annual Meeting. March 19 - 24, 2022. Los Angeles, CA
2022.01
Celnovte Biotechnology 2022 Medlab Middle East
2021.05
p16/Ki-67 Dual-staining Cytology
2020.08
Estrogen receptor (ER)-mAb clone C6H7 has got NordiQC assessment
Download CD15/CD56/CDX2 assessments on the DOCUMENTATION DOWNLOAD of this website. Also can download them on NordiQC website https://www.nordiqc.org/epitope.php
2020.10
The Nobel Prize in Chemistry 2020 was awarded jointly to Emmanuelle Charpentier and Jennifer A. Doudna "for the development of a method for genome editing."
HER2-mAb clone C1F7 has got NordiQC assessment
Progesterone receptor (PR)-mAb clone C4D10 has got NordiQC assessment
English 
